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KMID : 1094020130300010012
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Journal of Veterinary Clinics
2013 Volume.30 No. 1 p.12 ~ p.16
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Protective Effect of Rutin on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats
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Hwang Eui-Kyung
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Abstract
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This study was performed to investigate hepatoprotective effect of rutin on acute hepatic damage induced by carbon tetrachloride in rats. Twenty-four male Sprague-Dawley rats were randomly divided into four groups; normal control group, CCl4 control group, two rutin treatment groups (rutin 200+CCl₄ and rutin 400+CCl₄). Dissolving vehicles were applied to the rats in the normal control group. The rutin was administrated to the rats in rutin 200+CCl4 and rutin 400+CCl₄ groups at the levels of 200 mg/kg and 400 mg/kg, 3 consecutive days orally, with 24 hours interval before inoculating CCl₄. CCl₄ was intraperitoneally administered an hour after the last treatment of rutin to the rats in every group except the normal control group. The body weight of rats in CCl₄ control group were significantly lower than other groups (p < 0.05), but the liver weight and relative liver weight were higher than normal control group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in sera of rats in CCl₄ control group were higher and the levels of total protein, albumin and globulin were lower than the normal group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in rutin 200+CCl₄ and rutin 400+CCl₄ groups were lower than CCl₄ control group (p < 0.05). Therefore the pre-treatment of rutin before CCl₄ inoculation in rats effectively inhibited the elevation of serum ALT, AST and total bilirubin which are the parameters of hepatic damage.
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KEYWORD
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rutin, CCl₄, ALT, bilirubin, rat
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